The physical examination may be normal until COPD is fairly advanced.
As disease progresses, signs of hyperinflation may become more prominent.
Wheezing is occasionally observed
Persistently localized wheezing raises the possibility of lung cancer.
During COPD exacerbations, signs of respiratory distress may be prominent, including tachycardia, tachypnea, use of accessory muscles of respiration, and cyanosis.